Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release

Urate has emerged as a promising target for neuroprotection based on epidemiological observations, preclinical models, and early clinical trial results in multiple neurologic diseases, including Parkinson's disease (PD). This study investigates the astrocytic mechanism of urate's neuroprot...

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Bibliographic Details
Main Authors: Rachit Bakshi, Hong Zhang, Robert Logan, Ila Joshi, Yuehang Xu, Xiqun Chen, Michael A. Schwarzschild
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300371