Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies

Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies

Abstract Pre- and post-transplantation anti-MICA antibody detection development are associated with an increased rejection risk and low graft survival. We previously generated HLA class I null HEK-293T using CRISPR/Cas9, while MICA and MICB genes were removed in this study. A panel of 11 cell lines...

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Bibliographic Details
Main Authors: Ji-Ho Jeon, In-Cheol Baek, Cheol-Hwa Hong, Ki Hyun Park, Hyeyoung Lee, Eun-Jee Oh, Tai-Gyu Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95058-8

Internet

https://doi.org/10.1038/s41598-021-95058-8

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