Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte

Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte

Abstract Background Peripheral neuromuscular dysfunctions were found in elderly individuals, and spinal microglia/monocyte plays an important role on this process. This study aims to test whether the glial cell line-derived neurotrophic factor (GDNF) could attenuate age-related neuromuscular dysfunc...

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Bibliographic Details
Main Authors: Fei Xie, Fan Zhang, Su Min, Jingyuan Chen, Jun Yang, Xin Wang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Geriatrics
Subjects:
Aging
Neuromuscular dysfunction
Microglia/monocyte
Spinal cord
Nicotinic acetylcholine receptors
Online Access:http://link.springer.com/article/10.1186/s12877-018-0796-1

Internet

http://link.springer.com/article/10.1186/s12877-018-0796-1

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