Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

NIS and related bacteriocins are of interest as candidates for the treatment of human infections caused by Gram-positive pathogens such as Staphylococcus aureus. An important liability of NIS in this regard is the ease with which S. aureus acquires resistance. Here we establish that this organism na...

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Bibliographic Details
Main Authors: Christopher P. Randall, Arya Gupta, Bret Utley-Drew, Siu Yi Lee, Genevieve Morrison-Williams, Alex J. O’Neill
Format: Article
Language:English
Published: American Society for Microbiology 2018-12-01
Series:mSphere
Subjects:
Online Access:https://doi.org/10.1128/mSphereDirect.00633-18