Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution
Background “Quantile-dependent expressivity” refers to a genetic effect that is dependent upon whether the phenotype (e.g., spirometric data) is high or low relative to its population distribution. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and the FEV1/FVC ratio are m...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2020-05-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/9145.pdf |