AJP001, a novel helper T‐cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine

AJP001, a novel helper T‐cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine

Abstract Vaccine design requires well‐tailored formulations including a T‐cell epitope and adjuvants. We identified a novel cationic peptide, AJP001, which possesses a strong affinity for murine MHC class II alleles (H2‐IEd and H2‐IAd) and low affinity for H2‐IAb. We designed an AJP001 and epitope p...

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Bibliographic Details
Main Authors: Akiko Tenma, Hironori Nakagami, Hideki Tomioka, Makoto Sakaguchi, Ryoko Ide, Hiroshi Koriyama, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:FASEB BioAdvances
Subjects:
peptide
T‐cell epitope
vaccine
Online Access:https://doi.org/10.1096/fba.2019-00056

Internet

https://doi.org/10.1096/fba.2019-00056

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