The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

Alzheimer's dementia commonly impacts the health of older adults and lacks any preventative therapy. While Alzheimer's dementia risk has a substantial genetic component, the specific molecular mechanisms and neuropathologies triggered by most of the known genetic variants are unclear. Resu...

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Bibliographic Details
Main Authors: Shinya Tasaki, Chris Gaiteri, Sara Mostafavi, Philip L. De Jager, David A. Bennett
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer's disease
polygenic risk score
PheWAS
brain pathology
multi omics
epigenome
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00699/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00699/full

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