Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis.

Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis.

FtsZ is an attractive target for antibiotic research because it is an essential bacterial cell division protein that polymerizes in a GTP-dependent manner. To find the seed chemical structure, we established a high-throughput, quantitative screening method combining fluorescence cross-correlation sp...

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Bibliographic Details
Main Authors: Shintaro Mikuni, Kota Kodama, Akira Sasaki, Naoki Kohira, Hideki Maki, Masaharu Munetomo, Katsumi Maenaka, Masataka Kinjo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4496089?pdf=render

Internet

http://europepmc.org/articles/PMC4496089?pdf=render

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