Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining

Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and members of the recently identified shieldin and CTC1...

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Bibliographic Details
Main Authors: Paola Francica, Merve Mutlu, Vincent A. Blomen, Catarina Oliveira, Zuzanna Nowicka, Anika Trenner, Nora M. Gerhards, Peter Bouwman, Elmer Stickel, Maarten L. Hekkelman, Lea Lingg, Ismar Klebic, Marieke van de Ven, Renske de Korte-Grimmerink, Denise Howald, Jos Jonkers, Alessandro A. Sartori, Wojciech Fendler, J. Ross Chapman, Thijn Brummelkamp, Sven Rottenberg
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310536

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http://www.sciencedirect.com/science/article/pii/S2211124720310536

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