Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe

Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe

Suppressor screening is a powerful method to identify genes that, when mutated, rescue the temperature sensitivity of the original mutation. Previously, however, identification of suppressor mutations has been technically difficult. Due to the small genome size of Schizosaccharomyces pombe, we devel...

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Bibliographic Details
Main Authors: Xingya Xu, Li Wang, Mitsuhiro Yanagida
Format: Article
Language:English
Published: Oxford University Press 2018-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Schizosaccharomyces pombe
temperature sensitive mutant
Suppressor screen
next-generation sequencing
chromosome segregation
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200048

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200048

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