New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

Alzheimer’s disease (AD) is characterized by irreversible and progressive loss of memory and cognition and profound neuronal loss. Current therapeutic strategies for the treatment of AD have been directed to a variety of targets with the aim of reversing or preventing the disease but, unfortunately,...

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Bibliographic Details
Main Authors: Stephanie Pacella, Lucia Grumetto, Francesco Barbato, Dario Ambrosini, Gianfabio Giorgioni, Hasan Türkez, Antonella Fontana, Ivana Cacciatore, Lisa Marinelli, Piera Sozio, Amelia Cataldi, Antonio Di Stefano
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
Alzheimer’s disease
beta amyloid peptide
flurbiprofen
γ-secretase
Online Access:http://www.mdpi.com/1420-3049/18/9/10747

Internet

http://www.mdpi.com/1420-3049/18/9/10747

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