(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

Heat shock proteins (Hsps), amongst them, Hsp70 and Hsp90 families, serve mainly as facilitators of protein folding (molecular chaperones) of the cell. The Hsp70 family of proteins represents one of the most important molecular chaperones in the cell. Plasmodium falciparum, the main agent of malaria...

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Bibliographic Details
Main Authors: Tawanda Zininga, Lebogang Ramatsui, Pertunia Bveledzani Makhado, Stanley Makumire, Ikechukwu Achilinou, Heinrich Hoppe, Heini Dirr, Addmore Shonhai
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
malaria
Plasmodium falciparum
(−)-epigallocatechin-3-gallate
PfHsp70-z
PfHsp70-1
molecular chaperone
functional associates
inhibitor
Online Access:https://www.mdpi.com/1420-3049/22/12/2139

Internet

https://www.mdpi.com/1420-3049/22/12/2139

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