Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function

Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function

Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the senescence-related p21 protein) and CDKN2A (encoding p16 and p14) in human ascendi...

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Bibliographic Details
Main Authors: Alexandra Palmer, Sarah Epton, Ellie Crawley, Marilisa Straface, Luke Gammon, Meghan M. Edgar, Yichen Xu, Shezan Elahi, Joanne Chin-Aleong, Joanne E. Martin, Cleo L. Bishop, Charles H. Knowles, Gareth J. Sanger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neuroscience
Subjects:
senescence
p16
aging
human
colon
myenteric neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.747067/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.747067/full

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