Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes.

Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes.

The microbiome influences adaptive immunity and molecular mimicry influences T cell reactivity. Here, we evaluated whether the sequence similarity of various antigens to the microbiota dampens or increases immunogenicity of T cell epitopes. Sets of epitopes and control sequences derived from 38 anti...

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Bibliographic Details
Main Authors: Sebastian Carrasco Pro, Cecilia S Lindestam Arlehamn, Sandeep K Dhanda, Chelsea Carpenter, Mikaela Lindvall, Ali A Faruqi, Clark A Santee, Harald Renz, John Sidney, Bjoern Peters, Alessandro Sette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5937769?pdf=render

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http://europepmc.org/articles/PMC5937769?pdf=render

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