Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

Summary Cells exposed to ER-stress undergo the Unfolded Protein Response (UPR) to avoid apoptosis, but may also activate autophagy. However, the signal for selection of one of these two protective responses is unknown. To clarify the key switch between autophagy and apoptosis, we examined the correl...

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Bibliographic Details
Main Authors: Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsuo
Format: Article
Language:English
Published: The Company of Biologists 2013-08-01
Series:Biology Open
Subjects:
ER-stress
Autophagy
ATF4
CHOP
PERK pathway
Online Access:http://bio.biologists.org/content/2/10/1084

Internet

http://bio.biologists.org/content/2/10/1084

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