How to normalize metatranscriptomic count data for differential expression analysis

Background Differential expression analysis on the basis of RNA-Seq count data has become a standard tool in transcriptomics. Several studies have shown that prior normalization of the data is crucial for a reliable detection of transcriptional differences. Until now it has not been clear whether an...

Full description

Bibliographic Details
Main Authors: Heiner Klingenberg, Peter Meinicke
Format: Article
Language:English
Published: PeerJ Inc. 2017-10-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/3859.pdf