Recruitment of Intratumoral CD103+ Dendritic Cells by a CXCR4 Antagonist-Armed Virotherapy Enhances Antitumor Immunity

Recruitment of Intratumoral CD103+ Dendritic Cells by a CXCR4 Antagonist-Armed Virotherapy Enhances Antitumor Immunity

Intratumoral dendritic cells play an important role in stimulating cytotoxic T cells and driving antitumor immunity. Using a metastatic ovarian tumor model in syngeneic mice, we explored whether therapy with a CXCR4 antagonist-armed oncolytic vaccinia virus activates endogenous CD103+ dendritic cell...

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Bibliographic Details
Main Authors: Anna Mistarz, Marcin P. Komorowski, Matthew A. Graczyk, Margaret Gil, Aimin Jiang, Mateusz Opyrchal, Hanna Rokita, Kunle O. Odunsi, Danuta Kozbor
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770519300658

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http://www.sciencedirect.com/science/article/pii/S2372770519300658

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