The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Abstract Treating M. abscessus infection is challenging due to the potent β-lactamase BlaMab (Beta-lactamase of M. abscessus ). Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit BlaMab. We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, av...

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Bibliographic Details
Main Authors: Michal Meir, Pablo Bifani, Daniel Barkan
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Antimicrobial Resistance and Infection Control
Subjects:
Mycobacterium abscessus
Combination treatment
Avibactam
Piperacillin
MIC
Online Access:http://link.springer.com/article/10.1186/s13756-018-0448-4

Internet

http://link.springer.com/article/10.1186/s13756-018-0448-4

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