Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin

Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin

Clostridium perfringens enterotoxin (CPE) is a common cause of food poisoning and hyperkalemia-associated death. Previously, we reported that fusion of pneumococcal surface protein A (PspA) to C-terminal fragment of CPE (C-CPE) efficiently bound mucosal epithelium so that PspA-specific immune respon...

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Bibliographic Details
Main Authors: Hidehiko Suzuki, Koji Hosomi, Ayaka Nasu, Masuo Kondoh, Jun Kunisawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
vaccine
food poisoning
Clostridium perfringens enterotoxin
cholera toxin
mucosal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02320/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02320/full

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