CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation

Extra-medullary disease (EMD) in multiple myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that lead to EMD have not been well defined. We developed bone marrow (BM)- and EMD-prone MM syngeneic cell lines; identified that epithelial-to-mes...

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Bibliographic Details
Main Authors: Aldo M. Roccaro, Yuji Mishima, Antonio Sacco, Michele Moschetta, Yu-Tzu Tai, Jiantao Shi, Yong Zhang, Michaela R. Reagan, Daisy Huynh, Yawara Kawano, Ilyas Sahin, Marco Chiarini, Salomon Manier, Michele Cea, Yosra Aljawai, Siobhan Glavey, Elizabeth Morgan, Chin Pan, Franziska Michor, Pina Cardarelli, Michelle Kuhne, Irene M. Ghobrial
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715006853

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http://www.sciencedirect.com/science/article/pii/S2211124715006853

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