Activation of the VEGF-A/ERK/PLA2 Axis Mediates Early Retinal Endothelial Cell Damage Induced by High Glucose: New Insight from an In Vitro Model of Diabetic Retinopathy

Activation of the VEGF-A/ERK/PLA2 Axis Mediates Early Retinal Endothelial Cell Damage Induced by High Glucose: New Insight from an In Vitro Model of Diabetic Retinopathy

Early blood retinal barrier (BRB) dysfunction induced by hyperglycemia was related to increased pro-inflammatory activity of phospholipase A2 (PLA2) and the upregulation of vascular endothelial growth factor A (VEGF-A). Here, we tested the role of VEGF-A in high glucose (HG)-induced damage of human...

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Bibliographic Details
Main Authors: Giovanni Giurdanella, Gabriella Lupo, Florinda Gennuso, Federica Conti, Debora Lo Furno, Giuliana Mannino, Carmelina Daniela Anfuso, Filippo Drago, Salvatore Salomone, Claudio Bucolo
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
phospholipase A2
retinal endothelium
VEGF-A
Aflibercept
high glucose
Online Access:https://www.mdpi.com/1422-0067/21/20/7528

Internet

https://www.mdpi.com/1422-0067/21/20/7528

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