Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair

The Lyme disease spirochete, Borrelia burgdorferi, uses antigenic variation as a strategy to evade the host’s acquired immune response. New variants of surface-localized VlsE are generated efficiently by unidirectional recombination from 15 unexpressed vls cassettes into the vlsE locus. Using algori...

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Bibliographic Details
Main Authors: Theodore B. Verhey, Mildred Castellanos, George Chaconas
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
antigenic variation
Borrelia burgdorferi, Lyme disease
vlsE
segmental gene conversion
expression locus
silent cassettes
error-prone repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307174

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http://www.sciencedirect.com/science/article/pii/S2211124718307174

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