IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice

IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice

Fructose is a strong risk factor for non-alcoholic fatty liver disease (NAFLD), resulting from the disruption of redox systems by excessive reactive oxygen species production in the liver cells. Of note, recent epidemiological studies indicated that women are more prone to developing metabolic syndr...

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Bibliographic Details
Main Authors: Jeong Hoon Pan, Hoe-Sung Kim, Kaleigh Elizabeth Beane, Allison Michelle Montalbano, Jin Hyup Lee, Young Jun Kim, Jun Ho Kim, Byungwhi Caleb Kong, Sangyub Kim, Jeen-Woo Park, Eui-Cheol Shin, Jae Kyeom Kim
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Nutrients
Subjects:
IDH2
fructose
NAFLD
NF-κB
female mice
Online Access:http://www.mdpi.com/2072-6643/10/6/679

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http://www.mdpi.com/2072-6643/10/6/679

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