Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation

The modulation of dynamic histone acetylation states is key for organizing chromatin structure and modulating gene expression and is regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. The mammalian SIRT6 protein, a member of the Class III HDAC Sirtuin family of NAD+...

Full description

Bibliographic Details
Main Authors: Wei Zheng, Luisa Tasselli, Tie-mei Li, Katrin F. Chua
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
SIRT6
Sirtuin
ACLY
histone acetylation
acetyl-CoA
chromatin
Online Access:https://www.mdpi.com/2073-4425/12/9/1460

Internet

https://www.mdpi.com/2073-4425/12/9/1460

Similar Items