Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg<sup>2+</sup> or Mn<sup>2+</sup> ions...

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Bibliographic Details
Main Authors: Robert Reiberger, Kateřina Radilová, Michal Kráľ, Václav Zima, Pavel Majer, Jiří Brynda, Martin Dračínský, Jan Konvalinka, Milan Kožíšek, Aleš Machara
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
bio-isosterism
cross-coupling
endonuclease inhibitor
flavonoids
influenza
Mannich reaction
Online Access:https://www.mdpi.com/1422-0067/22/14/7735

Internet

https://www.mdpi.com/1422-0067/22/14/7735

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