BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

Abstract Background Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no effective targeted therapies for PeM exist. Some immune checkpoi...

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Bibliographic Details
Main Authors: Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Fan Mo, Shawn Anderson, Stanislav Volik, Hans H. Adomat, Dong Lin, Hui Xue, Xin Dong, Robert Shukin, Robert H. Bell, Brian McConeghy, Anne Haegert, Sonal Brahmbhatt, Estelle Li, Htoo Zarni Oo, Antonio Hurtado-Coll, Ladan Fazli, Joshua Zhou, Yarrow McConnell, Andrea McCart, Andrew Lowy, Gregg B. Morin, Tianhui Chen, Mads Daugaard, S. Cenk Sahinalp, Faraz Hach, Stephane Le Bihan, Martin E. Gleave, Yuzhuo Wang, Andrew Churg, Colin C. Collins
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Medicine
Subjects:
Peritoneal mesothelioma
BAP1
Genomics
Tumor immunosurveillance
Precision oncology
Online Access:http://link.springer.com/article/10.1186/s13073-019-0620-3

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http://link.springer.com/article/10.1186/s13073-019-0620-3

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