Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2

Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2

Somatosensory low threshold mechanoreceptors (LTMRs) sense innocuous mechanical forces, largely through specialized axon termini termed sensory nerve endings, where the mechanotransduction process initiates upon activation of mechanotransducers. In humans, a subset of sensory nerve endings is enlarg...

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Bibliographic Details
Main Authors: Shuyong Zhu, Nancy Stanslowsky, Jorge Fernández-Trillo, Tamrat M. Mamo, Pengfei Yu, Norman Kalmbach, Birgit Ritter, Reto Eggenschwiler, Werner J.D. Ouwendijk, David Mzinza, Likai Tan, Andreas Leffler, Michael Spohn, Richard J.P. Brown, Kai A. Kropp, Volkhard Kaever, Teng-Cheong Ha, Pratibha Narayanan, Adam Grundhoff, Reinhold Förster, Axel Schambach, Georges M.G.M. Verjans, Manuela Schmidt, Andreas Kispert, Tobias Cantz, Ana Gomis, Florian Wegner, Abel Viejo-Borbolla
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Stem Cell Research
Subjects:
Human induced pluripotent stem cells
Small molecule-derived neural precursor cells
Low threshold mechanoreceptors
Bulbous sensory nerve ending
Piezo1, Piezo2
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003822

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http://www.sciencedirect.com/science/article/pii/S1873506121003822

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