Development, Optimization, and Validation of a High Throughput Screening Assay for Identification of Tat and Type II Secretion Inhibitors of Pseudomonas aeruginosa

Development, Optimization, and Validation of a High Throughput Screening Assay for Identification of Tat and Type II Secretion Inhibitors of Pseudomonas aeruginosa

Antibiotics are becoming less effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa. Antimicrobial therapies based on the inhibition of specific virulence-related traits, as opposed to growth inhibitors, constitute an innovative and appealing approach to tackle th...

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Bibliographic Details
Main Authors: Francesco Massai, Michael Saleeb, Tugrul Doruk, Mikael Elofsson, Åke Forsberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Pseudomonas aeruginosa
high-throughput screening
twin arginine translocase
type II secretion
virulence inhibitors
phospholipase C
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00250/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00250/full

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