The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.

The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.

Purinergic P2X and P2Y receptors are broadly expressed on both neurons and glial cells in the central nervous system (CNS), including dentate gyrus (DG). The aim of this research was to determine the synaptic and proliferative response of the DG to severe oxygen and glucose deprivation (OGD) in acut...

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Main Authors: Giovanna Maraula, Daniele Lana, Elisabetta Coppi, Francesca Gentile, Tommaso Mello, Alessia Melani, Andrea Galli, Maria Grazia Giovannini, Felicita Pedata, Anna Maria Pugliese
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115273

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https://doi.org/10.1371/journal.pone.0115273

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