Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling

Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling

Abstract Background Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosis. TGF-beta-induced myofibroblast differentiation characterized by expr...

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Bibliographic Details
Main Authors: Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert Guzy, Gökhan M. Mutlu, Nickolai O. Dulin
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Respiratory Research
Subjects:
Tannic acid
Pulmonary fibrosis
TGF-beta
Smad2
Myofibroblast
Online Access:http://link.springer.com/article/10.1186/s12931-019-1141-8

Internet

http://link.springer.com/article/10.1186/s12931-019-1141-8

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