Mitogen-activated protein kinases regulate expression of neuronal nitric oxide synthase and neurite outgrowth via non-classical retinoic acid receptor signaling in human neuroblastoma SH-SY5Y cells

Mitogen-activated protein kinases regulate expression of neuronal nitric oxide synthase and neurite outgrowth via non-classical retinoic acid receptor signaling in human neuroblastoma SH-SY5Y cells

We have previously shown that retinoic acid receptor (RAR) stimulation by an agonist Am80 recruits nitric oxide-dependent signaling via increased expression of neuronal nitric oxide synthase (nNOS) in rat midbrain slice cultures. Using neuroblastoma SH-SY5Y cells, here we investigated the mechanisms...

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Bibliographic Details
Main Authors: Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Koichi Shudo, Hiroshi Katsuki
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Retinoid
Neurite morphogenesis
Nitric oxide
Mitogen-activated protein kinase
PI3 kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001942

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http://www.sciencedirect.com/science/article/pii/S1347861315001942

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