Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells

Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells

The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα and ChREBPβ. However, the mechanism responsible...

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Bibliographic Details
Main Authors: Lan Li, Haruhiko Sakiyama, Hironobu Eguchi, Daisaku Yoshihara, Noriko Fujiwara, Keiichiro Suzuki
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:FEBS Open Bio
Subjects:
ChREBPα
ChREBPβ
ERK
oxidative stress
staurosporine
Online Access:https://doi.org/10.1002/2211-5463.13208

Internet

https://doi.org/10.1002/2211-5463.13208

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