Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates.

Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates.

Recent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemics. We investigated immunogenicity and protective efficacy of a multi-antigen (MA) universal influenza DNA vaccine consisting of HA, M2, and NP antigens in cynomolgus macaques. Following challen...

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Bibliographic Details
Main Authors: Merika T Koday, Jolie A Leonard, Paul Munson, Adriana Forero, Michael Koday, Debra L Bratt, James T Fuller, Robert Murnane, Shulin Qin, Todd A Reinhart, Karen Duus, Ilhem Messaoudi, Amy L Hartman, Kelly Stefano-Cole, Juliet Morrison, Michael G Katze, Deborah Heydenburg Fuller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5739435?pdf=render

Internet

http://europepmc.org/articles/PMC5739435?pdf=render

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