The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042

The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042

The frequent dysregulation of SRC family kinases (SFK) in multiple cancers prompted various inhibitors to be actively tested in preclinical and clinical trials. Disappointingly, dasatinib and saracatinib failed to demonstrate monotherapeutic efficacy in patients with head and neck squamous cell carc...

Full description

Bibliographic Details
Main Authors: Francisco Hermida-Prado, M. Ángeles Villaronga, Rocío Granda-Díaz, Nagore del-Río-Ibisate, Laura Santos, Maria Ana Hermosilla, Patricia Oro, Eva Allonca, Jackeline Agorreta, Irati Garmendia, Juan Tornín, Jhudit Perez-Escuredo, Rocío Fuente, Luis M. Montuenga, Francisco Morís, Juan P. Rodrigo, René Rodríguez, Juana M. García-Pedrero
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Journal of Clinical Medicine
Subjects:
head and neck squamous cell carcinoma
SRC
dasatinib
saracatinib
cancer stem cells
EC-8042
Online Access:https://www.mdpi.com/2077-0383/8/8/1157

Internet

https://www.mdpi.com/2077-0383/8/8/1157

Similar Items