NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development

Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk of developing asthma later in life. Previously, our group has shown that RSV infection in mice and infants promotes IL-1β production. Here, we characterized the role o...

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Bibliographic Details
Main Authors: Carrie-Anne Malinczak, Charles F. Schuler, Angela J. Duran, Andrew J. Rasky, Mohamed M. Mire, Gabriel Núñez, Nicholas W. Lukacs, Wendy Fonseca
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/4/692