Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progressionResearch in context

Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progressionResearch in context

Background: While androgen deprivation therapy (ADT) and radiotherapy (RT) are currently used together to treat locally advanced prostate cancer (PCa), RT might have the adverse effect of increasing the PCa androgen receptor (AR) protein expression, which might then increase the resistance to contin...

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Bibliographic Details
Main Authors: Fu-Ju Chou, Yuhchyau Chen, Dong Chen, Yuanjie Niu, Gonghui Li, Peter Keng, Shuyuan Yeh, Chawnshang Chang
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418306273

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http://www.sciencedirect.com/science/article/pii/S2352396418306273

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