PD-1 Expression by Lymph Node and Intratumoral Regulatory T Cells Is Associated with Lymph Node Metastasis in Pancreatic Cancer

PD-1 Expression by Lymph Node and Intratumoral Regulatory T Cells Is Associated with Lymph Node Metastasis in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a mostly immunosuppressive microenvironment. Tumor-draining lymph nodes (TDLN) are a major site for priming of tumor-reactive T cells and also tumor metastasis. However, the phenotype and function of T cells in TDLNs from PDAC patients is u...

Full description

Bibliographic Details
Main Authors: Adrian M. Seifert, Annabel Eymer, Max Heiduk, Rebekka Wehner, Antje Tunger, Janusz von Renesse, Rahel Decker, Daniela E. Aust, Thilo Welsch, Christoph Reissfelder, Jürgen Weitz, Marc Schmitz, Lena Seifert
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
pancreatic cancer
tumor-draining lymph nodes
T cells
Treg cells
PD-1
Online Access:https://www.mdpi.com/2072-6694/12/10/2756

Internet

https://www.mdpi.com/2072-6694/12/10/2756

Similar Items