TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections

TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections

Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF-β signaling pathway-related genes cause heritable disorders of the connective tissue, such...

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Bibliographic Details
Main Authors: Norifumi Takeda, Hironori Hara, Takayuki Fujiwara, Tsubasa Kanaya, Sonoko Maemura, Issei Komuro
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
Marfan syndrome
Loeys-Dietz syndrome
Shprintzen-Goldberg syndrome
fibrillin-1
endothelial dysfunction
angiotensin II
TGF-β paradox
Online Access:http://www.mdpi.com/1422-0067/19/7/2125

Internet

http://www.mdpi.com/1422-0067/19/7/2125

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