A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects

A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects

The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding domain with 1,25(OH)2D3 or gemini analogs unveiled th...

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Bibliographic Details
Main Authors: Tiphaine Huet, Gilles Laverny, Fabrice Ciesielski, Ferdinand Molnár, Thanuja Gali Ramamoorthy, Anna Y. Belorusova, Pierre Antony, Noelle Potier, Daniel Metzger, Dino Moras, Natacha Rochel
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714010985

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http://www.sciencedirect.com/science/article/pii/S2211124714010985

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