Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression

The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying autoimmune diseases due to its early onset and the possibility to analyze cells derived from the site of inflammation. Epigen...

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Bibliographic Details
Main Authors: Janneke G.C. Peeters, Stephin J. Vervoort, Sander C. Tan, Gerdien Mijnheer, Sytze de Roock, Sebastiaan J. Vastert, Edward E.S. Nieuwenhuis, Femke van Wijk, Berent J. Prakken, Menno P. Creyghton, Paul J. Coffer, Michal Mokry, Jorg van Loosdregt
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009316

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http://www.sciencedirect.com/science/article/pii/S2211124715009316

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