Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance

Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance

Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis. While prophylaxis has reduced the incidence of PCP, its use has raised concerns about deve...

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Bibliographic Details
Main Authors: Laurence Huang, Kristina Crothers, Chiara Atzori, Thomas Benfield, Robert Miller, Meja Rabodonirina, Jannik Helweg-Larsen
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2004-10-01
Series:Emerging Infectious Diseases
Subjects:
perspective, Pneumocystis, Pneumocystis jirovecii, pneumonia, Pneumocystis, dihydropteroate synthase, dihydrofolate reductase, mutation, trimethoprim-
drug resistance, microbial
Online Access:https://wwwnc.cdc.gov/eid/article/10/10/03-0994_article

Internet

https://wwwnc.cdc.gov/eid/article/10/10/03-0994_article

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