Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

Summary: E2F transcription factors control the expression of cell-cycle genes. Cancers often demonstrate enhanced E2F target gene expression, which can be explained by increased percentages of replicating cells. However, we demonstrate in human cancer biopsy specimens that individual neoplastic cell...

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Bibliographic Details
Main Authors: Hendrika A. Segeren, Lotte M. van Rijnberk, Eva Moreno, Frank M. Riemers, Elsbeth A. van Liere, Ruixue Yuan, Richard Wubbolts, Alain de Bruin, Bart Westendorp
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
cell cycle
anaphase-promoting complex/cyclosome
E2F transcription
live-cell imaging
single-cell RNA sequencing
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314388

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http://www.sciencedirect.com/science/article/pii/S2211124720314388

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