Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro

Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro

Abstract Background Multiple myeloma is an incurable complex disease characterized by clonal proliferation of malignant plasma cells in a hypoxic bone marrow environment. Hypoxia-dependent erythropoietin (EPO)-receptor (EPOR) signaling is central in various cancers, but the relevance of EPOR signali...

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Bibliographic Details
Main Authors: Thea Kristin Våtsveen, Anne-Marit Sponaas, Erming Tian, Qing Zhang, Kristine Misund, Anders Sundan, Magne Børset, Anders Waage, Gaute Brede
Format: Article
Language:English
Published: BMC 2016-08-01
Series:Journal of Hematology & Oncology
Subjects:
Multiple myeloma
CD138+ cells
Erythropoietin
Erythropoietin-receptor
JAK-2
ERK-1/2
Online Access:http://link.springer.com/article/10.1186/s13045-016-0306-x

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http://link.springer.com/article/10.1186/s13045-016-0306-x

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