Interferon-gamma increases the ratio of matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 in peripheral monocytes from patients with coronary artery disease.

Acute coronary syndromes (ACS) may be triggered by acute infections. Systemic production of interferon gamma (IFN-γ) is induced during infection and regulates the production of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), both important in plaque stability. This study evaluates the...

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Main Authors: Rashidi Springall, Luis M Amezcua-Guerra, Hector Gonzalez-Pacheco, Janette Furuzawa-Carballeda, Lorena Gomez-Garcia, Ricardo Marquez-Velasco, Ana María Mejía-Domínguez, Jorge Cossío-Aranda, Carlos Martínez-Sánchez, Rafael Bojalil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3741271?pdf=render