Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group

Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group

Abstract Background Dexrazoxane protects from lower-cumulative-dose doxorubicin cardiotoxicity, but the effect of dexrazoxane in children with sarcoma treated with higher-cumulative-dose doxorubicin is unknown. Methods We evaluated children with osteosarcoma (OS) on two Children’s Oncology Group tri...

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Bibliographic Details
Main Authors: Lisa M. Kopp, Richard B. Womer, Cindy L. Schwartz, David H. Ebb, Vivian I. Franco, David Hall, Donald A. Barkauskas, Mark D. Krailo, Holcombe E. Grier, Paul A. Meyers, Leonard H. Wexler, Neyssa M. Marina, Katherine A. Janeway, Richard Gorlick, Mark L. Bernstein, Steven E. Lipshultz, for the Children’s Oncology Group
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cardio-Oncology
Subjects:
Osteosarcoma
Pediatrics
Cardiotoxicity
Doxorubicin
Online Access:http://link.springer.com/article/10.1186/s40959-019-0050-9

Internet

http://link.springer.com/article/10.1186/s40959-019-0050-9

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