Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts

Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts

5-Hydroxymethylcytosine (5hmC) is a functionally active epigenetic modification. We analyzed whether changes in DNA 5-hydroxymethylation are an element of age-related epigenetic drift. We tested primary fibroblast cultures originating from individuals aged 22–35 years and 74–94 years. Global quantit...

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Bibliographic Details
Main Authors: Paulina Kołodziej-Wojnar, Joanna Borkowska, Zofia Wicik, Anna Domaszewska-Szostek, Jacek Połosak, Marta Cąkała-Jakimowicz, Olga Bujanowska, Monika Puzianowska-Kuznicka
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
dermal fibroblasts
aging
epigenetic drift
5-hydroxymethylcytosine (5hmC)
regions differentially hydroxymethylated with age (DHMRs)
ten-eleven translocation methylcytosine dioxygenase (TET) enzymes
Online Access:https://www.mdpi.com/1422-0067/22/1/78

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https://www.mdpi.com/1422-0067/22/1/78

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