Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation

Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation

The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-<i>b</i>]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and anti...

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Bibliographic Details
Main Authors: Dimitrios T. Trafalis, Sofia Sagredou, Panayiotis Dalezis, Maria Voura, Stella Fountoulaki, Nikolaos Nikoleousakos, Konstantinos Almpanakis, Maria V. Deligiorgi, Vasiliki Sarli
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
1,2,4-triazolo[3,4-<i>b</i>]-1,2,4-thiadiazole
inhibitor of Akt phosphorylation
anticancer
MTT assay
HT-29 human colon tumor xenograft
ATP binding site
Online Access:https://www.mdpi.com/1999-4923/13/4/493

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https://www.mdpi.com/1999-4923/13/4/493

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