Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome

The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors. Here, we show abnormalities in neurogenesis in the mouse and human...

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Bibliographic Details
Main Authors: Topi A. Tervonen, Verna Louhivuori, Xiaohong Sun, Marie-Estelle Hokkanen, Claudius F. Kratochwil, Pawel Zebryk, Eero Castrén, Maija L. Castrén
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
Fmr1 knockout
Brain development
Differentiation
Glutamatergic
Neural progenitor cell
Tbr2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002611

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http://www.sciencedirect.com/science/article/pii/S0969996108002611

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