Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis

Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis

Abstract Background The toxicity and inefficient delivery of triptolide (TPL) in tumor therapy have greatly limited the clinical application. Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nanosystem composed of hyaluronic acid-vitamin E succinate and poly (β-amin...

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Bibliographic Details
Main Authors: Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao, Jinming Zhang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Triptolide
Nanoparticles
Breast cancer
Lung metastasis
Low toxicity
Online Access:https://doi.org/10.1186/s12951-021-00934-0

Internet

https://doi.org/10.1186/s12951-021-00934-0

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