Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder

There is increasing evidence for disturbances within the glutamate system in patients with affective disorders, which involve disruptions of the glutamate-glutamine- cycle. The mainly astroglia-located enzyme glutamine synthetase catalyzes the ATP-dependent condensation of ammonia and glutamate to f...

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Bibliographic Details
Main Authors: Hans-Gert eBernstein, Gabriela eMeyer-Lotz, Henrik eDobrowlny, Jana eBannier, Johann eSteiner, Martin eWalter, Bernhard eBogerts
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Bipolar Disorder
Oligodendroglia
Cortex
astroglia
immunocytochemistry
major depression
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00273/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00273/full

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